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All Journal Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan EQUILIBRIUM Majalah Kedokteran Gigi Indonesia Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Jurnal Ilmiah Kedokteran Wijaya Kusuma Health Notions Multidiciplinary Journal Medical Technology and Public Health Journal Jurnal Mekanova : Mekanikal, Inovasi dan Teknologi Jurnal MID-Z (Midwivery Zigot) Jurnal Ilmiah Kebidanan Indonesian Journal of electronics, electromedical engineering, and medical informatics Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Journal of Telenursing (JOTING) Jurnal Surya Muda: Ilmu Keperawatan dan Ilmu Kesehatan AloHA International Journal of Health Advancement (AIJHA) Hang Tuah Medical Journal Journal for Quality in Public Health
Al Munawir
Department Of Pathology, Faculty Of Medicine, University Of Jember, Jember, 68121 Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Mechanical Engineering Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Kedokteran Brawijaya

 1 
Anti-Metastatic Effect of Boiled Garlic Extract on A549 Lung Cancer Cells Line by FAK Mechanism Munawir, AL
Jurnal Kedokteran Brawijaya Vol 28, No 4 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (952.846 KB) | DOI: 10.21776/ub.jkb.2015.028.04.6

Abstract

According to epidemiological and animal study, the daily intake of garlic have important role in decreasing of cancer prevalence and tumor metastasis. However, mechanism of anti-metastatic of garlic is not fully understood. In the present study, we examined the anti metastatic effect of a brief exposure to boiled garlic extract (BGE) on A549 Lung cancer cells. Cytotoxicity BGE on A549 lung cancer cells was tested using MTT Assay. Migration and invasion scratching wound assay A549 lung cancer cells was tested usingscratching wound assay and agarose dropt explants assay.The growth of A549 lung cancer cell was measured using Colony forming assay. To explore the molecular mechanism and effect of BGE on migration and invasion, western blotting was used to analyze the FAK/Paxillin pathway. We found that BGE inhibits the growth, migration and invasion  of A549 lung cancer cells at 300 µg/mL. Interestingly, BGE inhibits migration and invasion of A549lung cancer cells by decreasing the total of FAK and P-Y397 expression at 6 hours after a brief exposure, but not influence of the paxillin expression. We think the present finding demonstrate a novel anti-metastatic effect of garlic and suggests a certain garlic-derived compounds, BGE may be potential agent for inhibiting migration and invasion through decreasing the total of FAK and P-Y397 expression in the cancer cell.  Keywords: A549 lung cancer cells, boiled garlic extract, FAK mechanism, migration cell
Co-Authors Ade Ananta Pratiwi Adelia Handoko Adinningtyas Intansari Agung Sudrajat Agung_Sudrajat Agung Aini Hidayati Ali Santoso Alimas Jonsa Anang Dwi Atmoko Ancah Caesarina Novi Marchianti Anhar Fazri Asti Nuris ASTUTI, IDA SRI SURANI WIJI Ayik Nikmatul Laili Ayik Nikmatul laili Azka Darajat Bagus Indra Kusuma Dear F Sielma Desy Tariustanti Desy Tariustanti Dewi Rokhmah Edy Kurniawan Elfian Zulkarnain Elfian Zulkarnain, Elfian Erfan Efendi Erma Sulistyaningsih Fadhly, Zuhrizal Farida Wahyu Ningtyias, Farida Wahyu Farida Wahyuningtiyas Farizal, Teuku Fazlina, Rita Ghiza J.K. Barqly Hadi Prayitno Hazmi Dwinanda Nurqistan Herdi Susanto Herri Darsan Hilda Khairinnisa I Gusti Ngurah Agung Darma Putra Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Ikmala, Riskita Isa Marufi ISLAMI, SHOFI IQDA Jumanto Jumanto Kiky Martha Ariesaka kustin uds Laili, Ayik Nikmatul Laksmi Indreswari Luluk Faridatul Mukaromah Mudzakkir Taufiqurrahman Murhaban Murhaban Murtadho Ridwan Nadia Putri Yurianto Nafolion Nur Rahmat Nafolion Nur Rahmat, Nafolion Nur Nanda Prima Natasya Febrilia Yulianti Novan K. Adji Pandan wangi Pandan Putri Erlinda Kusumaningarum Putri Kemala Sari Retno Widyastuti Riskita Ikmala Rizka N Wardani Roat Yeti Mustafida Rosita Dewi Sabrina M Pratama Saiful Bukhori Saiful Bukhori Saiful Bukhori Salman Al Farisi Sarwendah Siswi Winasis Sayyidah Auliany Aminy septa surya wahyudi, septa surya SHOFI IQDA ISLAMI Silvi Ahmada Chasya Sri Wahyu Handayani, Sri Wahyu Sugiyanta Sugiyanta Supangat Supangat Supangat Supangat Supangat Syari, Zammiq Ummah, Wiqodatul Vita Alfiatul Hasanah Wahyu Dian Puspita Wiqodatul Ummah Zahrah Febianti Zarah Puspita Zarah Puspitaningtyas